abstract：OBJECTIVE:To study the expression of tumor necrosis factor receptor-associated protein 1 (TRAP1) in gastric cancer tissue and its correlation with malignant biology. METHODS:Gastric cancer tissue and adjacent normal tissue were collected, and mRNA content and protein content of TRAP1 were detected; gastric cancer cell...

journal_title：Asian Pacific journal of tropical medicine

authors： Han P,Wang QL,Zhang X

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To assess the effect potency, and the immunomodulatory response of garlic oil extract in enhancing the host's immune system against the disorders caused by Schistosoma mansoni (S. mansoni) in mice at different stages of worm maturation. METHODS:A total of 70 male CD-1 Swiss albino mice were divided into 7 gr...

journal_title：Asian Pacific journal of tropical medicine

authors： Kamel ROA,El-Shinnawy NA

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To build the rat model of gastric precancerous lesions and discuss the effect of transplantation of mesenchymal stem cells (BMMSCs) on the pathological change. METHODS:The rat model of gastric precancerous lesions was built using N-methyl-N'-nitro-N'-nitrosoguanidine. After the intravenous transplantation of...

journal_title：Asian Pacific journal of tropical medicine

authors： Lin ZL,Zheng GW,Zhang L,Zheng JT,Chen H

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To investigate the propensity of plumbagin to inhibit the three isoforms of human cytochrome P450 (CYP), i.e., CYP1A2, CYP2C19, and CYP3A4 using human liver microsomes in vitro. METHODS:Inhibitory effects of plumbagin on the three human CYP isoforms were investigated using pooled human liver microsomes. Phen...

journal_title：Asian Pacific journal of tropical medicine

authors： Sumsakul W,Chaijaroenkul W,Na-Bangchang K

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:To explore the regulatory role of thioredoxin-interacting protein (TXNIP) in Wnt/β-catenin signaling pathway and therefore to elucidate its function in diabetic myocardial infarction. METHODS:Diabetic myocardial infarction models were generated in mice. The expression levels of TXNIP and β-catenin and level ...

journal_title：Asian Pacific journal of tropical medicine

authors： Yu H,Zhao XX,Shan XH,Li P,Chen T

更新日期：2015-11-01 00:00:00

abstract：:The 2014 Ebola outbreak in West Africa, primarily affecting Guinea, Sierra Leone, and Liberia, has exceeded all previous Ebola outbreaks in the number of cases and in international response. Although infections only occur frequently in Western Africa, the virus has the potential to spread globally and is classified as...

journal_title：Asian Pacific journal of tropical medicine

authors： Andreas A,Binoun A Egom C,Kruzliak P,Egom EE

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To explore the regulation effect of Rheum palmatum (R. palmatum) L. on NF-κB signaling pathway of ALF mice. METHODS:The intraperitoneal injection of d-GalN/LPS was employed for the model building. Mice in the treatment group and positive control group were given the R. palmatum L. and bifendate before the mo...

journal_title：Asian Pacific journal of tropical medicine

authors： Zhang RZ,Qiu H,Wang N,Long FL,Mao DW

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To invest the differences among mesenchymal stem cells (MSCs) derived from different tissues and their impacts on clinical applications. METHODS:In this study, MSCs were isolated from adipose tissue (AD), umbilical cord tissue (UC), and menstrual blood (Men) and compared their biological characteristics in t...

journal_title：Asian Pacific journal of tropical medicine

authors： Chen JY,Mou XZ,Du XC,Xiang C

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To study the expression of caveolin-1 in colorectal adenocarcinoma tissues and its correlation with microlymphatic vessel density (LMVD), and to investigate the clinical pathological prognostic significance of caveolin-1 and LMVD in patients with colorectal cancer. METHODS:The expression of caveolin-1 and LM...

journal_title：Asian Pacific journal of tropical medicine

authors： Xue J,Wu XL,Huang XT,Guo F,Yu HF,Zhang PC,Wang LK,Qu M,Pan LM

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:To analyze the protective efficacy of recombinant 78 kDa antigen of Leishmania donovani in combination with two adjuvants, that is, cationic liposomes or MPL-A against visceral leishmaniasis in BALB/c mice. METHODS:The genomic DNA of promastigotes was isolated and 583 bp of T cell epitopes of gene encoding 7...

journal_title：Asian Pacific journal of tropical medicine

authors： Nagill R,Kaur T,Joshi J,Kaur S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between genetic factor and prostate cancer (Pca) risk and the possible cause in it. METHODS:The polymorphisms of cytochrome P450 family 17 (CYPl7) rs743572, p27 V109G and androgen receptor (AR) gene CAG repeat length in peripheral blood from 70 cases and 70 controls were detec...

journal_title：Asian Pacific journal of tropical medicine

authors： Han QH,Shan ZJ,Hu JT,Zhang N,Zhang XP

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To establish the prevalence and associated risk factors of Schistosoma mansoni (S. mansoni) infection among schoolchildren at a village in Wolaita Zone, Southern Ethiopia. METHODS:A cross-sectional study was carried out among primary schoolchildren. A total of 384 randomly selected study subjects provided st...

journal_title：Asian Pacific journal of tropical medicine

authors： Alemayehu B,Tomass Z

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To explore the role of miR-214 in the progression of hepatocellular carcinoma (HCC) and its inhibitory mechanisms in depressing the signaling pathway of β-catenin, this study was conducted. METHODS:We ectopically expressed miR-214 in HepG2 cells to obtain cell lines Lv-miR-214-HepG2 and their control Lv-cont...

journal_title：Asian Pacific journal of tropical medicine

authors： Zhang LL,Guo YJ,Zhao CN,Gao JY

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To describe the profile and geographical distribution of reported cases of cutaneous leishmaniasis (CL) in the province of Hail, Saudi Arabia from 2010 to 2013. METHODS:Human data were collected from the dermatology service of both King Khaled and General Hail hospitals. RESULTS:A total of 483 confirmed CL ...

journal_title：Asian Pacific journal of tropical medicine

authors： Haouas N,Amer O,Ishankyty A,Alazmi A,Ishankyty I

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To determine antibiotic resistance patterns and virulence potential of Campylobacter jejuni (C. jejuni) isolates from clinical human diarrheal infections, cattle and healthy broilers. METHODS:Antibiotic sensitivity patterns of C. jejuni isolates were determined by Kirby Bauer Disc Diffusion assay. These isol...

journal_title：Asian Pacific journal of tropical medicine

authors： Siddiqui FM,Akram M,Noureen N,Noreen Z,Bokhari H

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To confirm dengue infection among Russian tourists returned from Southeast and Mexico in 2010-2013 with clinical signs of infection. METHODS:Blood and serum samples from patients were collected. NS1 antigen and human IgM/IgG antibodies to dengue virus were identified using commercial tests manufactured by "S...

journal_title：Asian Pacific journal of tropical medicine

authors： Sergeeva EI,Ternovoi VA,Chausov EV,Berillo SA,Demina OK,Shikov AN,Plasunova IV,Kartashov MJ,Agafonov AP

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on an experimental murine colitis model. METHODS:Experimental colitis was induced by dextran sulfate sodium (DSS), and mice were divided into 4 groups: control, DSS alone, DSS plus ...

journal_title：Asian Pacific journal of tropical medicine

authors： Miao XP,Sun XN,Cui LJ,Cao QF,Zhuang GF,Deng TZ,Zhang DY

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To survey the prevalence severe diarrhea arising from these bacteria in children under 5 years old in Marvdasht. METHODS:In this study faecal sample from 615 children aged <5 years old who were hospitalized for gastroenteritis in Fars hospitals in Iran were collected and then enriched in Escherichia coli (E....

journal_title：Asian Pacific journal of tropical medicine

authors： Kargar M,Homayoon M

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of rhPTH (1-34) vs. elcatonin. METHODS:Sixty patients with primary OP were randomly divided into two groups according to the ratio of 3:1. rhPTH (1-34) group (PTH group) was treated with subcutaneous injection of rhPTH (1-34) 20 μ g daily for 18 months, and the elcatonin g...

journal_title：Asian Pacific journal of tropical medicine

authors： Yang Y,Zhang XJ,Zhu XJ,Zhang L,Bao MJ,Xian Y,Wu JC,Liu LM,Li PQ

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To develop attenuated strains of Salmonella enterica serovar Typhi (S. typhi) for the candidate vaccine by osmolar stress. METHODS:S. typhi SS3 and SS5 strains were isolated from asymptomatic typhoid carriers in Namakkal, Tamil Nadu, India. Both strains were grown in LB (Luria Bertani) medium supplemented wi...

journal_title：Asian Pacific journal of tropical medicine

authors： Senthilkumar B,Anbarasu K,Senbagam D,Rajasekarapandian M

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To investigate the therapeutic effect of the intervention treatment with different doses of Captopril on TNF-αcontents in serum of rheumatoid arthritis (RA) rats, and to provide the theoretical proofs for clinical application of Captopril in treatments of rheumatoid diseases. METHODS:Fifty Wistar rats were r...

journal_title：Asian Pacific journal of tropical medicine

authors： Liu HM,Wang KJ

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To observe the effect of recombinant human bone morphogenetic protein 2/poly-lactide-co-glycolic acid (rhBMP-2/PLGA) with core decompression on repair of rabbit femoral head necrosis. METHOD:Bilateral femoral head necrosis models of rabbit were established by steroid injection. A total of 48 rabbits (96 femo...

journal_title：Asian Pacific journal of tropical medicine

authors： Pan ZX,Zhang HX,Wang YX,Zhai LD,Du W

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:To build GPC3 gene short hairpin interference RNA (shRNA) slow virus vector, observe expression of Huh-7 GPC3 gene in human liver cell line proliferation apoptosis and the effect of GPC3 gene influencing on liver cancer cell growth, and provide theoretical basis for gene therapy of liver cancer. METHODS:Hep...

journal_title：Asian Pacific journal of tropical medicine

authors： Lei CJ,Yao C,Pan QY,Long HC,Li L,Zheng SP,Zeng C,Huang JB

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:To do mapping and modeling of conformational B cell epitope regions of highly conserved and protective regions of three merozoitecandidate vaccine proteins of Plasmodium vivax (P. vivax), ie. merozoite purface protein-1 (PvMSP-1), apical membrane antigen -1 domain ∏ (PvAMA1-D∏) and region ∏ of the Duffy bind...

journal_title：Asian Pacific journal of tropical medicine

authors： Amarasinghe S,Kathriarachchi H,Udagama P

更新日期：2014-10-01 00:00:00

abstract：:Harmony is defined as the pleasing combination of elements of a system to form an all-inclusive, all involving and more productive team. The aim of this present review was to investigate the factors militating against harmony among healthcare professional in the Nigerian healthcare delivery system. This review was car...

journal_title：Asian Pacific journal of tropical medicine

authors： Osaro E,Charles AT

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To determine the impact of seasonal variations on health indices of free-ranging asymptomatic guinea fowls (Numida meleagris) in Zambia. METHODS:A time series analysis was carried out on a prospective cohort study over a 12 month period between March 2010 and February 2011 by examining a total 147 guinea fow...

journal_title：Asian Pacific journal of tropical medicine

authors： Nalubamba KS,Mudenda NB,Bwalya EC,Masuku M,Munyeme M,Munang'andu HM

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To investigate the biosorption potential of isolated bacteria as an alternative biosorbent material for the removal of zinc and nickel from aqueous solution in a bubble column bioreactor. METHORDS:In this study from four points of waste water treatment plant, some Gram-positive and Gram-negative bacteria und...

journal_title：Asian Pacific journal of tropical medicine

authors： Arjomandzadegan M,Rafiee P,Moraveji MK,Tayeboon M

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the pharmacognostic characters of Limonia acidissima L. (L. acidissima) leaf and stem, an important traditional medicinal plant. METHODS:The present study provides pharmacognostic, physicochemical and phytochemical details of leaf and stem of L. acidissima. Micro and macroscopic characters were a...

journal_title：Asian Pacific journal of tropical medicine

authors： Pandavadra M,Chanda S

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To optimize the process parameters involved in the green synthesis of silver nanoparticles (G-SNPs) by aqueous extract of Rosa damascena petals and to evaluate the biocompatibility and anti cancer activity of the synthesized silver nanoparticles against human lung adenocarcinoma (A549). METHODS:The process v...

journal_title：Asian Pacific journal of tropical medicine

authors： Venkatesan B,Subramanian V,Tumala A,Vellaichamy E

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To determine the phytochemical composition, antioxidant and anticancer activities of ethanolic and water leaves extracts of Annona muricata (A. muricata) from the Eastern Uganda. METHODS:Phytochemical screening was conducted using standard qualitative methods and a Chi-square goodness of fit test was used to...

journal_title：Asian Pacific journal of tropical medicine

authors： Gavamukulya Y,Abou-Elella F,Wamunyokoli F,AEl-Shemy H

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To investigate antiviral activity of maca to reduce viral load in Madin-Darby canine kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and Flu-B, respectively). METHODS:Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the extracts were evaluated on MDCK c...

journal_title：Asian Pacific journal of tropical medicine

authors： Del Valle Mendoza J,Pumarola T,Gonzales LA,Del Valle LJ

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To evaluate antioxidant and radical scavenging activities of organic extracts from fruit, roots and aerial parts of Fagonia cretica. METHODS:Shed dried and powdered plant parts were initially extracted in methanol and subsequently partitioned in n-hexane, chloroform, ethyl acetate and 1-butanol successively....

journal_title：Asian Pacific journal of tropical medicine

authors： Iqbal P,Ahmed D,Asghar MN

更新日期：2014-09-01 00:00:00

abstract：:A natural prodrug is a chemical compound or substance obtained from plants, microorganism, animal and marine sources. Natural products are small molecule source for Food and Drug Administration approved drugs and major sources for drug discovery. Most of the drugs for different ailment diseases undergo first pass meta...

journal_title：Asian Pacific journal of tropical medicine

authors： Kumar SV,Saravanan D,Kumar B,Jayakumar A

更新日期：2014-09-01 00:00:00

abstract：:Clostridium difficile is a Gram-positive, strictly anaerobic, spore-forming bacterium. It is the most common cause of antibiotic-associated diarrhea in hospitals and other healthcare facilities and is of significant concern because of the increasing morbidity and mortality rates as well as increased health care costs....

journal_title：Asian Pacific journal of tropical medicine

authors： Khan FY,Elzouki AN

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To study the involvement of variations in 4 genes associated with susceptibility and/or protection against HIV-1 in serodiscordant couples in Burkina Faso, namely, genes encoding HLA-B57, interferon regulatory factor 1 (IRF1), dendritic cell-specific ICAM3-grabbing nonintegrin (DC-SIGN) and CCR5 delta 32 (CCR...

journal_title：Asian Pacific journal of tropical medicine

authors： Kagoné TS,Bisseye C,Méda N,Testa J,Pietra V,Kania D,Yonli AT,Compaoré TR,Nikiéma JB,de Souza C,Simpore J

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To draw on data about publication patterns and citation indicators of Asian Pacific Journal of Tropical Medicine (APJTM) during 2008 and June 2014 in order to know about the current state of the journal. METHODS:Data used in this study were collected based on publications in APJTM from 2008 to June, 2014. In...

journal_title：Asian Pacific journal of tropical medicine

authors： Lei Y,Tan BJ,Zou Z,Zhang MM,Song RP,Qu SH,Li J

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To evaluate parasite distribution and tissue tropism of Toxoplasma gondii tachyzoites in experimentally infected mice using real time QPCR. METHODS:In this survey 16 Balb/c mice were inoculated with 1 × 10(4) alive tachyzoites of Toxoplasma gondii RH strain. After 1, 2, 3 days post infection and the last day...

journal_title：Asian Pacific journal of tropical medicine

authors： Dadimoghaddam Y,Daryani A,Sharif M,Ahmadpour E,Hossienikhah Z

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To observe the effect of Rougan Huaqian granules combined with human mesenchymal stem cell (hMSC) transplantation on the liver fibrosis in carbon tetrachloride-induced cirrhosis rats. METHODS:Sixty SD rats were randomly divided into five groups. The rats in control group received intraperitoneal injection of...

journal_title：Asian Pacific journal of tropical medicine

authors： Wang ZC,Yang S,Huang JJ,Chen SL,Li QQ,Li Y

更新日期：2014-07-01 00:00:00

abstract：:This paper reviews the existing depth of anaesthesia (DoA) monitors and their algorithms and also proposes to improve their performance from four aspects. An ideal DoA monitor should be able to suggest a personalised drug dosage, to predict and provide early warnings when dosages are inappropriate, to be portable and ...

journal_title：Asian Pacific journal of tropical medicine

authors： Li TN,Li Y

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To investigate the correlation between nasopharyngeal carcinoma cell WNT5A and epithelial-mesenchymal transition (emt)/metastasis, and investigate its possible mechanisms. METHODS:RT-PCR and gene transfection were used to detect the expression of nasopharyngeal carcinoma cell strains WNT5A and EMT related fa...

journal_title：Asian Pacific journal of tropical medicine

authors： Zhu HH,Zhu XY,Zhou MH,Cheng GY,Lou WH

更新日期：2014-06-01 00:00:00